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Deoxyribonucleic acid, also known as DNA, is a crucial molecule that carries genetic information from one generation to another. Considering its significance, it is necessary for the students pursuing molecular biology in Australian universities to obtain detailed information about the structure and functionalities.
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An Overview on Deoxyribonucleic Acid
Nucleic acids are significant in featuring the information-carrying molecules of body cells. They regulate the protein synthesis process and determine the inherited characteristics of living organisms.
The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Deoxyribonucleic acid is the principal component of life, and it creates the genetic substances in all living beings. DNA comprises four nucleotides such as A, C, G, and T, and the four are combined together with the support of alternating phosphate and deoxyribose sugar deposits.
The DNA is made of nucleotides, the biological building blocks; deoxyribonucleic acid is one of the most crucial; molecules are not only for human beings but also for all the living organisms out there. It features hereditary elements and genes which differentiate the human from each other. Genome is the set of DNA which houses three billion bases, 23 pairs of chromosomes and 20,000 genes. In general, humans inherit half of the DNA from the father and half from the mother itself.
Chemical Structure of Deoxyribonucleic Acid
The chemical DNA was discovered in the latter part of the eighteenth century, but it is the year 1953 when James Watson and Francis Crick determined DNA structure based on the work of Rosalind Franklin and Maurie Wilkins. Structurally DNA is a double-helix polymer and also a spiral featuring two DNA strands coiled around each other.
Each of the constituents of the DNA molecule is made of a long string of monomer nucleotides which consists of a deoxyribose sugar molecule, a phosphate group along with one of four nitrogenous roots such as
Two purines, adenine and guanine, and two pyrimidines, cytosine and thymine. Covalent bonds combine the nucleotides, and the strand of DNA is enfolded the other by hydrogen bonds between two bases.
Biological structures of Deoxyribonucleic Acid
The DNA molecules that occur naturally are circular or linear. For example, the genomes of single-celled bacteria and prokaryotes and the genomes of mitochondria and chloroplasts are circular.
On the other hand, the genomes of eukaryotes feature linear DNA molecules known as chromosomes. Human DNA consists of 23 pairs of linear chromosomes. In every cell, DNA exists as a protein-coated complex known as chromatin, which regulates gene expression and ascertains chromosomes' characteristic shape.
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